Thea Brabb, D.V.M., Ph.D., Dipl. ACLAM
Professor Emeritus
D.V.M., University of Illinois 1985
Ph.D.
P: 206-685-9346
F: 206-685-3006
E: thea@uw.edu
About Dr. Brabb
Dr. Thea Brabb is an emeritus Professor of the Department of Comparative Medicine (DCM). Her primary research is in investigating how infectious agents modulate the development of autoimmunity and cancer, with the majority of her work focused on mouse models of inflammatory bowel disease. Dr. Brabb served as the Attending Veterinarian for the University of Washington from 2005 to 2017 and Chair of DCM from 2017 to 2024. She retired in July of 2024.
Selected Publications
Ellis MM, Brune JE, Patil K, Brabb TL. Ammonia for Determination of Cage-change Frequency in Antelope Ground Squirrels (Ammospermophilus leucurus). .J Am Assoc Lab Anim Sci. 2024 Mar 7. doi: 10.30802/AALAS-JAALAS-23-000047.
Seamons A, Staucean, O, Snyder, J, Brabb T, Hsu, C, Paik J. 2023. ALDH1A Inhibition Suppresses Colitis and Alters α4β7 Integrin Expression on Activated T Cells in Mdr1a−/− Mice. Nutrients. 15 (18):3883 doi: 10.3390/nu15183883
Stepien TA, Libby SJ, Karlinsey JE, Brehm MA, Greiner DL, Shultz LD, Brabb T, Fang FC. 2022. Analysis of Salmonella Typhi Pathogenesis in a Humanized Mouse Model. Methods Mol Biol. (2427):215-234. doi: 10.1007/978-1-0716-1971-1_18.PMID: 35619037
Haenisch M, Nguyen T, Fihn CA, Goldstein AS, Amory JK, Treuting P, Brabb T, Paik J. 2021 Investigation of an ALDH1A1-specific inhibitor for suppression of weight gain in a diet-induced mouse model of obesity. Int J Obes (Lond). 45(7):1542-1552. doi: 10.1038/s41366-021-00818-1.
Felgenhauer JL, Brune JE, Long ME, Manicone AM, Chang MY, Brabb TL, Altemeier WA, Frevert CW. 2020. Evaluation of Nutritional Gel Supplementation in C57BL/6J Mice Infected with Mouse-Adapted Influenza A/PR/8/34 Virus. Comp Med. Dec 1;70(6):471-486. doi: 10.30802/AALAS-CM-20-990138. PMID: 33323164
Seamons A, Haenisch M, Meeker S, Pershutkina O, Brabb T, Treuting PM, Paik J. 2020. Protective Effects of ALDH1A Enzyme Inhibition on Helicobacter-Induced Colitis in Smad3-/- Mice are Associated with Altered α4ß7 Integrin Expression on Activated T Cells. Nutrients.;12(10):2927. doi: 10.3390/nu12102927. PMID: 32987910
Meeker SM, Seamons A, Treuting PM, Paik J, Brabb T, Hsu CC, Grady WM, Maggio-Price L. 2020. Effect of Chronic Vitamin D Deficiency on the Development and Severity of DSS-Induced Colon Cancer in Smad3-/- Mice. Comp Med. 70(2):120-130. doi: 10.30802/AALAS-CM-19-000021.PMID: 32014085
Hsu CC, Patil K, Seamons A, Brabb TL, Treuting PM, Paik J, Meeker SM, Maggio-Price L. 2020. Lack of Effect of Murine Norovirus Infection on the CD4+ CD45RBhigh T-cell Adoptive Transfer Mouse Model of Inflammatory Bowel Disease. Comp Med. 70(1):16-24. doi: 10.30802/AALAS-CM-19-000009. PMID: 31937392
Paik J, Meeker S, Hsu CC, Seamons A, Pershutkina O, Snyder JM, Brabb T, Maggio-Price L. 2019. Validation studies for germ-free Smad3-/- mice as a bio-assay to test the causative role of fecal microbiomes in IBD. Gut Microbes. 11(1):21-31. doi: 10.1080/19490976.2019.1611151 PMID: 31138018
Seamons A, Treuting PM, Meeker S, Hsu C, Paik J, Brabb T, Escobar SS, Alexander JS, Ericsson AC, Smith JG, Maggio-Price L. 2018. Obstructive Lymphangitis Precedes Colitis in Murine Norovirus-Infected Stat1-Deficient Mice. Am J Pathol. 188(7):1536-1554. doi: 10.1016/j.ajpath.2018.03.019. PMID: 29753791