cell biology
December 5, 2022
New blood test can detect ‘toxic’ protein years before Alzheimer’s symptoms emerge, study shows
Researchers at the University of Washington have detected “toxic” small aggregates of a particular protein in the blood of individuals with Alzheimer’s disease, as well as in individuals who showed no signs of cognitive impairment at the time the blood sample was taken, but who developed it at a later date. This blood test picks up oligomers — or small, misfolded aggregates — of the amyloid beta protein, which scientists believe triggers the development of Alzheimer’s.
January 25, 2022
Hungry yeast are tiny, living thermometers
University of Washington researchers report that yeast cells can actively regulate a process called phase separation in one of their membranes. During phase separation, the membrane remains intact but partitions into multiple, distinct zones or domains that segregate lipids and proteins. The new findings show for the first time that, in response to environmental conditions, yeast cells precisely regulate the temperature at which their membrane undergoes phase separation.
February 13, 2020
Immune cells consult with neighbors to make decisions
Scientists and physicians have long known that immune cells migrate to the site of an infection, which individuals experience as inflammation — swelling, redness and pain. Now, researchers at the University of Washington and Northwestern University have uncovered evidence that this gathering is not just a consequence of immune activation. Immune cells count their neighbors before deciding whether or not the immune system should kick into high gear.
February 4, 2020
First-of-its-kind hydrogel platform enables on-demand production of medicines and chemicals
A team of chemical engineers has developed a new way to produce medicines and chemicals and preserve them using portable “biofactories” embedded in water-based gels known as hydrogels. The approach could help people in remote villages or on military missions, where the absence of pharmacies, doctor’s offices or even basic refrigeration makes it hard to…
December 30, 2019
Life could have emerged from lakes with high phosphorus
Life as we know it requires phosphorus, which is scarce. So, how did a lifeless environment on the early Earth supply this key ingredient? A new UW study, published Dec. 30 in the Proceedings of the National Academy of Sciences, finds an answer to this problem in certain types of carbonate-rich lakes.
October 15, 2019
UW’s Ashleigh Theberge receives Packard Fellowship for research on cell communication signals
Ashleigh Theberge, a University of Washington assistant professor of chemistry, has been named a 2019 Packard Fellow for her research on cell signaling. Every year since 1988, the David and Lucile Packard Foundation has awarded Packard Fellowships in Science and Engineering to early-career scientists to pursue the types of innovative projects that often fall outside…
August 12, 2019
First cells on ancient Earth may have emerged because building blocks of proteins stabilized membranes
Scientists have discovered that the building blocks of proteins can stabilize cell membranes. This finding may explain how the first cells emerged from the primordial soup billions of years ago: The protein building blocks could have stabilized cell membranes against salt and ions that were present in ancient oceans. In addition, membranes may have been a site for these precursor molecules to co-localize, a potential mechanism to explain what brought together the ingredients for life.
May 29, 2019
New study identifies patterns of growth in chronic lymphocytic leukemia
In a paper published May 29 in Nature, scientists report that the growth of chronic lymphocytic leukemia is apt to follow one of three trajectories: relentlessly upward, steadily level or something in between. The particular course the disease takes is tightly linked to the genetic makeup of the cancer cells, particularly the number of growth-spurring “driver” mutations they contain.
April 15, 2019
Synthetic peptide can inhibit toxicity, aggregation of protein in Alzheimer’s disease, researchers show
A team led by researchers at the University of Washington has developed synthetic peptides that target and inhibit the small, toxic protein aggregates that are thought to trigger Alzheimer’s disease.
December 5, 2017
Living cell membranes can self-sort their components by ‘demixing’
Scientists at the University of Washington show for the first time that the complex distribution of molecules within a membrane of a living yeast cell arises through demixing.
July 17, 2017
Material from shellfish delivers a boost to bioassays and medical tests
Scientists at the University of Washington have discovered a simple way to raise the accuracy of diagnostic tests for medicine and common assays for laboratory research. By adding polydopamine — a material that was first isolated from shellfish — to these tests at a key step, the team could increase the sensitivity of these common bioassays by as many as 100 to 1,000 times.
February 16, 2017
Immune cell serves as an essential communications link for migrating cells
Scientists at the University of Washington have discovered that a common type of cell in the vertebrate immune system plays a unique role in communication between other cells. It turns out that these cells, called macrophages, can transmit messages between non-immune cells.
July 21, 2016
An engineered protein can disrupt tumor-promoting ‘messages’ in human cells
A team of researchers from the University of Washington and the University of Trento in Italy unveiled an engineered protein that they designed to repress a specific cancer-promoting message within cells.
July 11, 2016
UW researchers improve microscopy method to ‘swell’ cellular structures, bringing fine details into view
Scientists from the University of Washington recently reported a relatively simple method swell the tiny, complex structures within cells, bringing them within range of a common microscope’s resolving range.
June 17, 2015
Plants make big decisions with microscopic cellular competition
A team of University of Washington researchers has identified a mechanism that some plant cells use to receive complex and contradictory messages from their neighbors.
September 16, 2014
Health Sciences Digest: Wearable Artificial Kidney, worker wellness, chromosome sort safeguard
Health Sciences Digest: Wearable Artificial Kidney safety testing to begin, low-wage workers value employer wellness initiatives, cells simply avoid chromosome errors
November 24, 2013
How living cells solved a needle in a haystack problem to generate electrical signals
Filtered from a vast sodium sea, more than 1 million calcium ions per second gush through our cells’ pores to generate charges
August 7, 2013
UW researchers report on genome of aggressive cervical cancer that killed Henrietta Lacks
Henrietta Lacks was the subject of bestselling book on the HeLa immortal cell line, the most used of its kind in labs around the world. The UW scientists are the first to publish under new policy, established through agreement with Lacks’ family.
