Programmable proteins use logic to improve targeted drug delivery

October 9, 2025

Programmable proteins use logic to improve targeted drug delivery

A series of colorful shapes are arranged into two ring structures.

Targeted drug delivery is a powerful and promising area of medicine. Therapies that pinpoint precise areas of the body can reduce the medicine dosage and avoid potentially harmful “off target” effects. Researchers at the UW took a significant step toward that goal by designing proteins with autonomous decision-making capabilities. By adding smart tail structures to therapeutic proteins, the team demonstrated that the proteins could be “programmed” to act based on the presence of specific environmental cues.

January 30, 2024

Using computers to design proteins allows researchers to make tunable hydrogels that can form both inside and outside of cells

New research led by the UW demonstrates a new class of hydrogels that can form not just outside cells, but also inside of them. These hydrogels exhibited similar mechanical properties both inside and outside of cells, providing researchers with a new tool to group proteins together inside of cells.

January 18, 2021

Researchers use lasers and molecular tethers to create perfectly patterned platforms for tissue engineering

Researchers at the University of Washington have developed a technique to modify naturally occurring biological polymers with protein-based biochemical messages that affect cell behavior. Their approach, published the week of Jan. 18 in the Proceedings of the National Academy of Sciences, uses a near-infrared laser to trigger chemical adhesion of protein messages to a scaffold made from biological polymers such as collagen, a connective tissue found throughout our bodies.

May 20, 2019

Scientists use molecular tethers and chemical ‘light sabers’ to construct platforms for tissue engineering

In a paper published May 20 in the journal Nature Materials, a team of researchers from the University of Washington unveiled a new strategy to keep proteins intact and functional in synthetic biomaterials for tissue engineering. Their approach modifies proteins at a specific point so that they can be chemically tethered to the scaffold using light. Since the tether can also be cut by laser light, this method can create evolving patterns of signal proteins throughout a biomaterial scaffold to grow tissues made up of different types of cells.

January 16, 2018

Researchers program biomaterials with ‘logic gates’ that release therapeutics in response to environmental triggers

Drug treatments can save lives, but sometimes they also carry unintended costs. After all, the same therapeutics that target pathogens and tumors can also harm healthy cells. To reduce this collateral damage, scientists have long sought specificity in drug delivery systems: A package that can encase a therapeutic and will not disgorge its toxic cargo until it reaches the site of treatment — be it a tumor, a diseased organ or a site of infection. In a paper published Jan….