Z Yan Wang
May 12, 2022
Changes in cholesterol production lead to tragic octopus death spiral
After a mother octopus lays a clutch of eggs, she quits eating and wastes away; by the time the eggs hatch, she is dead. Some females in captivity even seem to speed up this process intentionally, mutilating themselves and twisting their arms into a tangled mess. The source of this bizarre maternal behavior seems to be the optic gland, an organ similar to the pituitary gland in mammals. For years, just how this gland triggered the gruesome death spiral was unclear. But in a new study published May 12 in Current Biology, researchers from the University of Washington, the University of Chicago and the University of Illinois Chicago show that the optic gland in maternal octopuses undergoes a massive shift in cholesterol metabolism, resulting in dramatic changes in the steroid hormones produced. Alterations in cholesterol metabolism in other animals, including humans, can have serious consequences on longevity and behavior, and the team believes this reveals important similarities in the functions of these steroids across the animal kingdom — in soft-bodied cephalopods and vertebrates alike.
